The biggest complaint with seating down the lines at U.S. Cellular Field is the angle towards home plate. Seats further down the line face the outfield too much and will have you turning your body to see the batter-pitcher exchange. Fortunately, none of these sections have more than ten seats in a row, so getting in and out is fairly painless.
Seats down the RF line will get the shade first, while seats down the LF line will have the best view of both color scoreboards. In addition, foul balls tend to pile up around sections 116-118 and 146-148.
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Section 153 tickets cost twice as much per game. In 154 you get a solid view down the line. A little far from the action but for the price it is well worth it.